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In about 5% of cases, leukoplakia turns cancerous and leads to oral, esophagus, or throat cancer

Most, if not all, are machine-made "domestic cigars" created from homogenized or reconstituted tobacco

Most Tobacco leaves are extracted and used in recipes by immersing them in sugar syrups, milk, or alcohol

The latest body of research suggests that heated tobacco products and their emissions contain many of the same harmful ingredients as regular cigarettes, and potentially other harmful ingredients not present in regular cigarettes