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Furthermore, these results at a cellular level in ASM are akin to the model of a high-fat, low-carbohydrate diet in smokers on nicotine replacement therapy (103) where chronic nicotine results in decreased glycolysis thereby preventing use of glucose as an energy source, which synergistically with increased breakdown of fatty acids contributes to malnutrition of chronic smokers

But the main producers are Italy, Bulgaria, Greece, Spain, and Poland, which together account for 85% of the EUs total tobacco output