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[232] [198] In addition to presynaptic actions that regulate DAT, TAAR1 activation exerts a somatodendritic inhibitory influence on midbrain dopamine neurons by reducing their firing rate via G protein-coupled inwardly-rectifying potassium channels, an effect that is expected to reduce action potential-dependent (vesicular) dopamine release into the synaptic cleft

Available at: [Accessed 23 August 2018] [47] Moodie C, Hastings G

Tobacco is a major part of the UK economy - In 202526 the government estimates tobacco duties will raise about 8.1 billion, accounting for 0.7% of all tax receipts The Chancellor has announced that duty on cigarettes will go up by the rate of inflation - likely to be the September RPI figure of 4.5%, plus two percentage points

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