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The pulmonary hydrocarbon receptor (AHR) is activated by benzo[a]pyrene (BaP), a component of cigarette smoke that binds to AHR and induces expression of P4501A1, or CYP1A1

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This analysis of drug harms in Canada found that alcohol causes the most harm overall Alcohol was followed by tobacco, nonprescription opioids (like fentanyl), cocaine, methamphetamine, and cannabis. Tobacco ranked first in 4 of the 16 harm categories: drug-related mortality, drug-specific damage to physical health, dependence, and environmental damage, the researchers wrote