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However, a 2016 study comparing the use of these medications to transdermal nicotine and placebo in more than 8,000 smokers with and without psychiatric comorbidities, found no significant difference in psychiatric adverse effects (Anthenelli RM et al, Monitor your depressed patients closely while starting treatment and tell them to contact you immediately if they experience sudden changes in mood or have suicidal thoughts

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Oral Surg Oral Med Oral Pathol 1982

R., Olfert, J

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