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In addition to the increased risk of cancer and other serious conditions, nicotine use can lead to: High blood pressure Increased heart rate Nausea Headaches Fatigue Anxiety and depression Negative effects on the cardiovascular system, especially for those with pre-existing cardiovascular conditions Long-term use of nicotine has also been linked to an increased risk of the following: Stroke Coronary artery disease Poor circulation While nicotine itself is not known to cause cancer, the American Cancer Society states that at least 70 chemicals found in tobacco smoke can cause cancer