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Those with asthma who are sensitive to cigarette smoke could also be triggered into a reaction or asthma attack when exposed to marijuana smoke (Allergy & Asthma Network)

In order to get rid of the agitation, the smoker lights up again and builds up a tolerance

Retrieved 15 February 2022

Lipid rafts are specific membrane domains containing cholesterol that act as a platform for many signaling pathways, including those related to inflammation [92]

[54] The inhaled substances trigger chemical reactions in nerve endings in the brain due to being similar to naturally occurring substances such as endorphins and dopamine, which are associated with sensations of pleasure