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Airway epithelial barrier dysfunction not only impairs the physical barrier activity of airway epithelium, but further exposes sub-epithelial layers to exogenous substances, leading to a series of pathological processes such as airway inflammation, airway remodeling, airway hyperresponsiveness and increasing the rate of COPD exacerbation [7, 8]

Tobacco smoke is a volatile compound with the ability to soak into everything soft and malleable

and the novels themselves are scarcely what we should to-day call by that name

Confronting coughs Most smokers develop a smokers cough

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