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Alternatively, optimizing the binding interface at the protein level by considering the 3D structural features of the target proteins could further improve the kinetic stability of the small molecule-target protein complex (Marchand et al., 2025)

Conversely, repleting GSH levels with precursors of its synthesis such as N-acetyl-cysteine (NAC) or 2-oxothiazolidine-4-carboxylic acid has protective effects