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It was found that the stiffening of the ECM impaired the differentiation of alveolar type II (AT2) epithelial cells into type I (AT1) cells 13,14 , which damaged the self-repairing abilities of alveolar structure

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The results directly indicated that the targeting motif RGD-binding peptide RGD-GHK almost totally suppressed the collagenase (MMP-1) expression, resisted H 2 O 2 -induced COL-1 degradation, and simultaneously promoted collagen synthesis compared with GHK alone for cell anti-aging performance