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Interestingly, co-culturing IGF-I +/+ osteoclast precursors (spleen cells from WT mice), with IGF-I / osteoblasts (bone marrow stromal cells from IGF-I KO mice), produces significantly fewer (by 90%) multi-nucleated osteoclasts than coculturing IGF-I +/+ osteoclast precursors with IGF-I +/+ osteoblasts, suggesting that osteoblasts may be a source of IGF-I to promote osteoclastogenesis

Is IV Therapy Worth It

(PubMed) The FDA (USA) explicitly warned compounders about using dietary-supplement-grade glutathione to make sterile injectables, after documented adverse events linked to endotoxin contamination

van Buul-Offers et al (1995) have shown that overexpression of IGF-2 in transgenic normal and pituitary deficient Snell dwarf mice causes increased growth of the thymus, suggesting a role for IGF-2 in thymic development by paracrine or autocrine mechanisms