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Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial

Important inflammatory factors such as cyclooxygenase 2 (COX-2), tumor necrosis factor (TNF-), and interleukin-6 (IL-6) are downregulated when prostaglandin E2 (PGE2) is inhibited (57)