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As for its role in protein synthesis, tryptophan is a precursor of crucial metabolites, such as 5-HT, which plays an essential role in functional gastrointestinal diseases ( The gut microbes in the third pathway can metabolize tryptophan into several molecules, such as indole and other derivatives compounds, with some of them acting as ligands to bind the aryl hydrocarbon receptor (AhR) (Williams et al., 2014

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