Following its dissociation from the a 2 -macroglobulin, the peptide is proteolytically cleaved to generate a C-terminal pentapeptide, which activates an intracellular Gi-protein-MAP kinase signalling pathway [232, 233]
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Why combination research differs from single-compound studies Combination studies require a different research design than single-compound studies, since researchers need to account for potential interactions between two active mechanisms rather than measuring a single variable in isolation
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