While the latter findings are also at odds with work showing that GLP-1Rs in glutamatergic rather than GABAergic neurons mediate the effects of chronic systemic liraglutide on energy balance in mice [55], they provide important insight into the neurochemical and neuroanatomical identity of a neuronal network targeted by GLP-1R agonists (Fig
doi: 10.3389/fonc.2025.1640238 Received 03 June 2025 Accepted 06 October 2025 Published 17 October 2025 Volume 15 - 2025 Edited by Supriya Mallick, All India Institute of Medical Sciences, India Reviewed by Otvio da Cunha Ferreira Neto, University of So Paulo, Brazil Adila Amariyil, University College London Hospitals NHS Foundation Trust, United Kingdom Updates Copyright 2025 Wang and Zhang
A pooled analysis of clinical trials found low rates of depression, anxiety, and suicidal ideation in Liraglutide (a GLP-1 agonist) vs placebo groups
Population Doubling Level Calculation To calculate the PDL, a formula was used as follows: n = 3.32 (log UCY log I ) + X , where n is the final PDL at the end of a given subculture, UCY is the cell yield at that point, I is the cell number used as inoculum to begin that subculture, and X is the PDL of the inoculum used to initiate the subculture being quantitated ( SA--Galactosidase Staining Cells were seeded in 6-well microplates at 4 10 4 cells/well
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
