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Liraglutide also has an FDA-approved obesity indication (Saxenda, 8.0% weight loss in SCALE), proven cardiovascular benefit (LEADER, 13% MACE reduction), and once-daily dosing without microsphere-related injection site reactions

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Together, our findings indicate that GSH synthesis in the liver is a crucial contributor to lipid abundance in vivo

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In the last step of the oxidative phase, ribulose 5-phosphate is converted to ribose 5-phosphate by the enzyme phosphopentose isomerase (Figure 4)