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In addition to these well-characterized metabolic activities, a number of novel biologic functions of GLP-1 have been shown to occur in animals and include: Regulation of -cell genes involved in glucose sensing and insulin biosynthesis and secretion Expansion of -cell mass through the proliferation and neogenesis of pancreatic cells Potentiation of glucose uptake in peripheral tissues

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When activated, it drives the production of TNF-alpha, IL-1beta, IL-6, COX-2, and hundreds of other pro-inflammatory mediators

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