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OS significantly impairs male fertility through disruption of sperm capacitation, induction of DNA damage such as sperm DNA fragmentation (SDF), reduced motility, and diminished sperm membrane fluidity

Alternative treatments might be recommended

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When a low dose of aspirin is administered orally (most commonly 81 mg), its context-sensitive drug disposition via the portal circulation combined with the difference in IC50 values for COX-1 vs COX-2 both contribute significantly to the high selectivity by which low dose oral aspirin inhibits platelet COX-1 vs other COX-2 found in other nucleated tissues such as the vascular endothelium (Pedersen & FitzGerald, 1984

Week-by-week timeline, side effect patterns, and dosing protocols inside