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Ensure your laboratory equipment is properly calibrated for a high-purity dsip profile before starting your preparation

However, small modifications to both the amino group and the methoxy group at position 5 of the benzothiazole core did not result in any significant increase or decrease in binding activity as measured by the CPMG assay, and no reliable LO-NMR K D data could be obtained for the analogues (Supplementary Table 1)

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This need for huge supra-physiologic doses indicates that folic acid alone is not a specific treatment