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IP 3 Rs play a central integrating and a crucial role in neurons, as evidenced by the involvement of IP3R-mediated calcium release in synaptic plasticity and memory [145, 150], neuronal excitability [146, 147], neurotransmitter release [148], axon growth [149], and long-term changes in gene expression [146]

The MRSD can be further refined based on the anticipated therapeutic window : the dosage range sitting between the minimum effective concentration (MEC) and the minimum toxic concentration (MTC)

However, the actual level and its measurement is also important to track and to understand

But escalating before your body adapts does not produce faster results