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Up-regulation of the PPP flux provides cells with R5P for nucleotide biosynthesis, as well as NADPH for biosynthesis and maintaining redox homeostasis (59, 67, 70)

It binds to these excess acetyl groups to form acetyl-carnitine, which safely removes them from the mitochondria and frees up unesterified Coenzyme A (CoA), a molecule absolutely vital for continued glucose and protein metabolism

Similarly, in atypical odontalgia and certain forms of trigeminal neuralgia, aberrant processing of proprioceptive input has been hypothesized to contribute to altered pain perception, potentially underpinned by abnormal electrophysiological properties of MTNs (Sessle, 2006)